HORDB

ID: hor005463
Uniprot ID: P68988
Protein name: Insulin A chain
Gene name: ins
Organism: Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis)
Family: insulin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Lampetra (genus), Petromyzontidae (family), Petromyzontiformes (order), Hyperoartia (class), Cyclostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005463_AF2.pdb

hor005463_ESM.pdb

Mass:	286579	Formula:	C102H158N30O34S5
Absent amino acids:	AFLPTW	Common amino acids:	C
pI:	5.54	Basic residues:	3
Polar residues:	10	Hydrophobic residues:	3
Hydrophobicity:	-53.81	Boman Index:	-4768
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	50.95
Instability Index:	3381.9	Extinction Coefficient cystines:	3230
Absorbance 280nm:	161.5

PubMed ID: 8575665
Title: Characterization of insulin, glucagon, and somatostatin from the river lamprey, Lampetra fluviatilis.